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  饒漢鈺

  助理研究員👨🏼‍🚒。2021年9月畢業於意昂4体育平台，獲理學博士學位🏋🏿‍♂️，同年就職於意昂4体育平台👁‍🗨，主要從事腫瘤相關基因在腫瘤中的機製研究和間充質幹細胞載體細胞免疫治療研究。近年來在腫瘤領域主流SCI期刊上發表論文數篇，已授權中國發明專利1項👮🏼‍♂️🌌。參與意昂4平台-悉尼大學合作研究項目⇢，曾於2019年赴澳大利亞悉尼大學意昂4体育平台訪學🤽🏻。主持國家自然科學基金青年科學基金項目1項🧘🏿，先後參與國家自然科學基金重點項目與面上項目、上海市科委等6項科研項目。

(1) 腫瘤相關基因在腫瘤發病中的功能機製
(2) 間充質幹細胞載體細胞免疫治療

1. Rao H, Liu C, Wang A, Ma C, Xu Y, Ye T, Su W, Zhou P, Gao WQ, Li L, Ding X. SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer. Nat Commun. 2023 Nov 21;14(1):7572.

2. Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ, Li L. Multilevel Regulation of β-Catenin Activity by SETD2 Suppresses the Transition from Polycystic Kidney Disease to Clear Cell Renal Cell Carcinoma. Cancer Res. 2021 Jul 1;81(13):3554-3567.

3. Rao H, Li X, Liu M, Liu J, Li X, Xu J, Li L, Gao WQ. DIRAS2 promotes renal cell carcinoma formation by activating the mitogen-activated protein kinase pathway in the absence of von Hippel-Lindau protein. Oncogene. 2020 May;39(19):3853-3866.

4. Feng W, Ma C, Rao H, Zhang W, Liu C, Xu Y, Aji R, Wang Z, Xu J, Gao WQ, Li L. Setd2 deficiency promotes gastric tumorigenesis through inhibiting the SIRT1/FOXO pathway. Cancer Lett. 2023 Nov 28;579:216470.

5. Liu C, Ni L, Li X, Rao H, Feng W, Zhu Y, Zhang W, Ma C, Xu Y, Gui L, Wang Z, Aji R, Xu J, Gao WQ, Li L. SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL. Clin Transl Med. 2023 Nov;13(11):e1468.

6. Ma C, Liu M, Feng W, Rao H, Zhang W, Liu C, Xu Y, Wang Z, Teng Y, Yang X, Ni L, Xu J, Gao WQ, Lu B, Li L. Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway. Clin Transl Med. 2023 Nov;13(11):e1475.

7. Liu M, Rao H, Liu J, Li X, Feng W, Gui L, Tang H, Xu J, Gao WQ, Li L. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021 Jul;43:102004.

9. Liu J, Feng W, Liu M, Rao H, Li X, Teng Y, Yang X, Xu J, Gao W, Li L. Stomach-specific c-Myc overexpression drives gastric adenoma in mice via AKT/mTOR signaling. Bosn J Basic Med Sci. 2020 Nov 19.