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  朱麟勇

         特聘教授，博士生導師🟥。1995在北京師範大學獲得本科學位🦠👨🏻‍🦳，2000年在中科院感光化學研究所獲得博士學位🤾🏿‍♂️，2003年至2007年⚅，先後在美國華盛頓州立大學和加州大學聖地亞哥分校從事博士後研究工作。2008年回國♓️🤵，被華東理工大學聘為特聘教授，2012年被聘為上海市“東方學者”特聘教授，2014年獲得國家傑出青年科學基金資助，2015年獲上海市“東方學者”跟蹤。2020年被意昂4平台聘為特聘教授🤭。

  長期聚焦於生物醫用材料，特別是“光化學方法構建生物醫用材料”方向。1）提出人工合成生色團的“擬熒光蛋白”的構建，創製高特異、高亮度👩‍🚒、從藍光至近紅外光發射任意調控的系列熒光探針😲，成功應用於蛋白與 mRNA 的熒光成像、定量以及相互作用等實時動態研究🙂‍↔️；2）提出“光偶聯反應”創新交聯機製，實施高機械強度與強組織粘附的水凝膠生物材料的超快構建➰，實現大動物心臟穿透傷導致大流量出血與動脈損傷的瞬時封閉🩷🍖，並由此推動醫用光敏生物膠領先技術的臨床轉化👨🏽‍🏫。這些成果發展光化學方法解決生命與醫學中的重要問題，充分體現“光”的可視與可控的獨特優勢。先後在Nat. Mater.、Nat. Biotechnol.🧛🏻、Nat. Chem. Biol.、Sci. Adv.🪈、Adv. Mater.🤐、J. Am. Chem. Soc.、Angew. Chem.🫱、Nat. Commun. 等學術期刊上發表論文百余篇，申/獲專利30余項。主持或負責國家重點研發計劃、軍委科技委🧑🏽‍🎤、國家自然科學基金、上海市人才計劃等二十余項項目。

1.  水凝膠生物材料（柔性可穿戴📑、組織工程與再生醫學）

2.  化學與生物熒光傳感 （熒光探針🤳🏿、體內體外檢測）

3.  光智能生物材料（3D打印人造器官）

4.  高精度生物芯片的光加工 （微流控芯片）

1.   Kaiyi Huang, Qianqian Song, Mengyue Fang, Deqiang Yao, Xin Shen, Xiaochen Xu, Xianjun Chen, Linyong Zhu*, Yi Yang*, Aiming Ren*, Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift. Nat. Chem. Biol. (IF =12.9), 2024, https://doi.org/10.1038/s41589-024-01633-1.

2.    Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen*, Linyong Zhu*, Yi Yang*, Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA. Nat. Chem. Biol. (IF =12.9), 2024, https://doi.org/10.1038/s41589-024-01629-x.

3.    Bingkun Bao, Qingmei Zeng, Kai Li, Jianfeng Wen, Yiqing Zhang, Yongjun Zheng, Renjie Zhou, Chutong Shi, Ting Chen, Chaonan Xiao, Baihang Chen, Tao Wang, Kang Yu, Yuan Sun, Qiuning Lin*, Yong He, Shantung Tu, Linyong Zhu*, Rapid fabrication of physically robust hydrogels. Nat. Mater. (IF = 37.2), 2023, 22, 1253-1260.

4.   Li Jiang, Xin Xie, Ni Su, Dasheng Zhang, Xianjun Chen*, Xiaochen Xu, Bibi Zhang, Kaiyi Huang, Jingwei Yu, Mengyue Fang, Bingkun Bao, Fangting Zuo, Lipeng Yang, Rui Zhang, Huiwen Li, Xinyi Huang, Zhengda Chen, Qingmei Zeng, Renmei Liu, Qiuning Lin, Yuzheng Zhao, Aiming Ren*, Linyong Zhu*, Yi Yang*, Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells. Nat. Methods (IF = 36.1), 2023, 20, 1563-1572.

5.    Tuan Liu, Bingkun Bao*, Yuzhan Li, Qiuning Lin, Linyong Zhu*, Photo-responsive polymers based on ο-Nitrobenzyl derivatives: from structural design to applications. Prog. Polym. Sci. (IF = 26.0), 2023, 146, 101741.

6.    Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, Xianjun Chen, Yihui Ge, Qiuning Lin, Lipeng Yang, Yujie Hua, Shuo Wang, Xin Hua, Fangting Zuo, Ningfeng Li, Renmei Liu, Li Jiang, Chunyan Bao, Yuzheng Zhao, Joseph Loscalzo, Yi Yang*, Linyong Zhu*, Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters. Cell Discov. (IF = 13.0), 2023 9, 56.

7.    Kaiyi Huang, Xianjun Chen, Chunyan Li, Qianqian Song, Huiwen Li, Linyong Zhu*, Yi Yang*, Aiming Ren*, Structure-based investigation of fluorogenic Pepper aptamer. Nat. Chem. Biol. (IF = 12.9), 2021, 17, 1289-1295.

8.   Wenjie Zhang, Bingkun Bao, Fei Jiang, Yiqing Zhang, Renjie Zhou, Yuezhi Lu, Sihan Lin, Qiuning Lin*, Xinquan Jiang*, Linyong Zhu*, Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S‐Nitrosylation Coupling Reaction. Adv. Mater. (IF = 27.4), 2021, 33, 2105667.

9.    Jian Zhang, Yongjun Zheng, Jimmy Lee, Jieyu Hua, Shilong Li, Ananth Panchamukhi, Jiping Yue, Xuewen Gou, Zhaofan Xia, Linyong Zhu*, Xiaoyang Wu*. A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing. Nat. Commun. (IF = 14.7), 2021, 12, 1670.

10.  Xianjun Chen, Dasheng Zhang, Ni Su, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Lixin Zhang, Yuzheng Zhao, Linyong Zhu*, Joseph Loscalzo, Yi Yang*, Visualizing RNA Dynamics in live cells with bright and stable fluorescent RNAs. Nat. Biotechnol. (IF = 33.1), 2019, 37, 1287-1293.

11.   Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Chengyao Ni, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Yiwei Zou, Dongsheng Yu, Jinwei Zhang, David E. Arnot, Boon Chin Heng, Xiaohui Zou, Linyong Zhu*, Shufang Zhang *, & Hongwei Ouyang*, A strongly adhesive haemostatic hydrogel for the repair of arterial and heart bleeds. Nat. Commun. (IF = 11.9), 2019, 10, 2060.

12.   Qiuning Lin, Lipeng Yang, Zhiqiang Wang, Yujie Hua, Dasheng Zhang, Bingkun Bao, Chunyan Bao, Xueqing Gong, Linyong Zhu*, Coumarin Photocages Modified with an Electron-Rich Styryl Moiety at the 3-Position: Long Wavelength Excitation, Rapid Photolysis and Photobleaching. Angew Chem Int. Ed. (IF = 16.1), 2018, 57, 3722.

13.   Sujun Chen, Yichun Wang, Ting Nie, Chunyan Bao*, Chenxi Wang, Tianyi Xu, Qiuning Lin, Da-Hui Qu, Xueqing Gong, Yi Yang, Linyong Zhu*, An artificial molecular shuttle operates in lipid bilayers for ion transport. J. Am. Chem. Soc. (IF = 14.4), 2018, 140, 17992.

14.  Zunzheng Ming, Jinyan Fan, Chunyan Bao*, Yuan Xue, Qiuning Lin, Linyong Zhu*, Photogenerated Aldehydes for Protein Patterns on Hydrogels and Guidance of Cell Behavior. Adv. Funct. Mater. (IF = 18.5), 2018, 1706918.

15.  Zunzheng Ming, Xing Ruan, Chunyan Bao*, Qiuning Lin, Yi Yang, Linyong Zhu*, Micropatterned Protein for Cell Adhesion through Phototriggered Charge Change in a Polyvinylpyrrolidone Hydrogel. Adv. Funct. Mater. (IF = 18.5), 2017, 27, 1606258.

16.   Yunlong Yang, Jieyuan Zhang, Zhenzhen Liu, Qiuning Lin*, Xiaolin Liu, Chunyan Bao, Yang Wang*, Linyong Zhu*, Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction. Adv. Mater. (IF = 27.4), 2016, 28, 2724-2730.

17.  Zhenzhen Liu, Tao Liu, Qiuning Lin, Chunyan Bao, Linyong Zhu*, Sequential Control over Thiol Click Chemistry by a Reversibly Photoactivated Thiol Mechanism of Spirothiopyran. Angew Chem Int. Ed. (IF = 16.1), 2015, 54, 174-178.

18.  Chunyan Bao, Linyong Zhu*, Qiuning Lin, He Tian, Building Biomedical Materials using Photochemical Bond Cleavage. Adv. Mater. (IF =27.4), 2015, 27, 1647-1662.

19.  Linzhi Zhao, Juanjuan Peng, Qi Huang, Chunyan Li, Min Chen, Yun Sun, Qiuning Lin, Linyong Zhu*, Fuyou Li*, Near-Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk-Shell Upconversion Nanocages. Adv. Funct. Mater. (IF = 18.5), 2014, 24, 363-371.

20.  Zhenzhen Liu, Qiuning Lin, Yun Sun, Tao Liu, Chunyan Bao, Fuyou Li, Linyong Zhu*, Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo-Uncaged-Thiol Michael Addition Reaction. Adv. Mater. (IF = 27.4), 2014, 26, 3912-3917.

21.   Qiuning Lin, Chunyan Bao, Yunlong Yang, Qiannan Liang, Dasheng Zhang, Shuiyu Cheng, Linyong Zhu*, Highly Discriminating Photorelease of Anticancer Drugs Based on Tumor- Hypoxia Activatable Phototriggers Conjugated Chitosan Nanoparticles. Adv. Mater. (IF = 27.4), 2013, 24, 1981-1986.

22.   Qiuning Lin, Chunyan Bao, Shuiyu Cheng, Yunlong Yang, Wei Ji, Linyong Zhu*, Target-Activated Coumarin Phototriggers Specifically Switch on Fluorescence and Photocleavage upon Bonding to Thiol-Bearing Protein. J. Am. Chem. Soc. (IF = 14.4), 2012, 134, 5052-5055.

23.   Qiuning Lin, Qi Huang, Chunyan Li, Chunyan Bao*, Zhenzhen Liu, Fuyou Li, Linyong Zhu*, Anticancer Drug Release from a Mesoporous Silica Based Nanophotocage Regulated by Either a One- or Two-Photon Process. J. Am. Chem. Soc. (IF = 14.4), 2010, 132, 10645-10647.

24.  Linyong Zhu, Wuwei Wu, Mingqiang Zhu, Jason J. Han, James K. Hurst*, Alexander D. Q. Li*, Reversibly Photoswitchable Dual-Color Fluorescence Nanoparticles as a New Tool for Cell Imaging. J. Am. Chem. Soc. (IF = 14.4), 2007, 129, 3524-3526.

25.   Linyong Zhu, Rafail F. Khairutdinov, James K. Hurst*, Photoregulated Transmembrane Charge Separation by Linked Spiropyran- Anthraquinone Molecules. J. Am. Chem. Soc. (IF = 14.4), 2006, 128, 825-835.

26.  Linyong Zhu, Mingqiang Zhu, James K. Hurst*, Alexander D. Q. Li*, Light-Controlled Molecular Switches Modulate Nanocrystal Fluorescence. J. Am. Chem. Soc. (IF = 14.4), 2005, 127, 8968-8970.