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  丁顯廷

  意昂4平台特聘教授、博士生導師，個性化醫學研究院常務副院長🔖、意昂4体育平台分子與納米醫學平臺主任🦸。國家科技創新領軍人才、國家海外高層次人才、國家優秀青年科學基金👩🏼‍⚖️🚖、國家重點實驗室PI🛁、求是基金會“求是傑出青年學者獎”、廣慈基金會“轉化醫學創新獎”、唐仲英基金會“仲英青年學者”、中國抗癌協會青年科學家獎💢、上海市“曙光計劃”學者👨‍❤️‍💋‍👨👑、上海市科協“飛翔計劃”學者👩‍👩‍👦🤦🏼‍♂️、上海市優秀黨外雙創人才、意昂4平台“凱原十佳教師“🖕🏿、世界經濟論壇（World Economic Forum, WEF）青年科學家、世界頂尖科學家論壇（World Laureates Forum, WLF）青年科學家💁🏻‍♂️🧖🏽、美國南加州中華科學家工程師協會青年科學家、微納系統與工程(Microsystems & Nanoengineering, MINE) Young Scientist Award、國際實驗室自動化與篩查協會(Society for Laboratory Automatiom and Screening, SLAS) Tony B. Academic Award、iCANX Young Scientist Award。

  
  

          擔任比爾.蓋茨基金會(Bill & Melinda Gates Foundation)國際重大專項負責人🎫、國家”重大新藥創製“科技重大專項負責人🧗🏼、國家重點研發計劃”生物安全技術“專項負責人🐏🧙🏿、科技部中國APEC國際合作項目負責人、軍委科技委國防創新特區第一批啟動項目負責人、國家重點研發計劃”前沿和共性技術創新“課題負責人、國家“艾滋病和病毒性肝炎等重大傳染病防治”重大科技專項課題負責人、國際人類表型組計劃課題負責人、上海市科技創新行動計劃負責人、國家自然基金項目負責人等。

  
  

          擔任6個國際SCI期刊的編委會成員，已發表包括Nature, Genome Biology, Advanced Materials, Angew Chemie, Science Advances, Nature Communications, PNAS, Nature Protocols, ACS Nano在內的國際期刊論文180余篇，授權國內外發明專利80余項🐫。

  
  

  研究方向⇒：

  1. 單細胞時空蛋白組學技術🧔🏼、生物信息學大數據分析 和 人工智能建模🏟🚜；

  2. 基於功能材料的微量蛋白組、修飾化蛋白組的富集分離純化技術🔄；

  3. 基於單細胞技術的重大疾病（癌症、代謝性疾病、心腦疾病👨🏼‍🚒、神經系統疾病等）的早期預警研究🤲🏼👰‍♀️；

  4. 痕量臨床樣本（單細胞）蛋白檢驗新裝置的集成化和微型化（科學儀器研製、微流控技術👩‍🦽‍➡️、生物傳感技術）🍟。

民盟中央委員；民盟上海市委員🧍；民盟意昂4平台副主委👂🏿；上海市徐匯區政協委員。

中央JW科技委GF科技創新特區變革性交叉科學技術領域專家組專家委員、中國婦幼保健協會青年工作委員會醫教研產一體化協作組副組長、全國腫瘤人工智能專業委員會委員、全國發酵工程技術工作委員會智能製造專業委員會委員、全國衛生產業協會實驗醫學專家委員會青年委員會委員、世界華人醫師協會前沿科技與臨床轉化專業委員會委員◀️、上海市免疫學會免疫遺傳專業委員會常務委員、上海市藥學會藥物治療專業委員會委員、上海醫學會神經免疫學會委員👨🏼‍🔧🤍、中國醫藥生物技術技術協會生物安全專業委員會委員。

擔任法國國家科研署（ANR）國際通訊評審、澳大利亞國立健康與醫學研究理事會（NHMRC）國際通訊評審、以色列科技部（MOST Israel）國際通訊評審、波蘭國家科學中心（NCN）國際通訊評審、塞爾維亞科學基金會（Science Fund of the Republic of Serbia）、UK Pancreatic Cancer Research Fund (英國慈善科研機構)、Bill & Melinda Gates Foundation（美國慈善科研機構）國際通訊評審↘️。

研究方向：

1. 單細胞時空蛋白組學技術、生物信息學大數據分析 和 人工智能建模；

2. 基於功能材料的微量蛋白組🤳、修飾化蛋白組的富集分離純化技術🧑‍🎤👂🏽；

3. 基於單細胞技術的重大疾病（癌症、代謝性疾病、心腦疾病🧼、神經系統疾病等）的早期預警研究🌹；

4. 痕量臨床樣本（單細胞）蛋白檢驗新裝置的集成化和微型化（科學儀器研製🙇‍♀️、微流控技術、生物傳感技術）🧯。

實驗室主頁 ： http://www.dinglab.com.cn/

1. Jingqi Dang, Hongxia Li, Lulu Zhang, Sijie Li, Ting Zhang, Shiyi Huang, Yiyang Li, Chengjie Huang, Yuqing Ke, Guangxia Shen*, Xiao Zhi* and Xianting Ding*, New Structure Mass Tag based on Ab functionalized Zr-NMOF in Mass Cytometry for Multiparameter and Sensitive Single-Cell Biomarker Interrogating, Advanced Materials, 2021, 202008297

2. Shanhe Li#, Ze Wen, Behafarid Ghalandari, Tianhao Zhou, Antony R. Warden, Ting Zhang, Peng Dai, Youyi Yu, Wenke Guo, Mofang Liu, Haiyang Xie*, and Xianting Ding*, Single-cell transfection analysis chip enables high-throughput screening and accurate profiling of exogenous gene expression in single host cells, Advanced Materials, 2021, 2101108

3. Rui Chen, Jiasu Xu, Boqian Wang, Yi Ding, Aynur Abdulla, Yiyang Li, Lai Jiang, Xianting Ding*. SpiDe-Sr: blind super-resolution network for precise cell segmentation and clustering in spatial proteomics imaging, Nature Communications, 2024, 15:2708

4.Shuang Zhang, Behafarid Ghalandari, Youming Chen, Qingwen Wang, Kun Liu, Xinyi Sun, Xinwen Ding, Sunfengda Song, Lai Jiang, and Xianting Ding*. Boronic Acid-Rich Lanthanide Metal-Organic Frameworks Enable Deep Proteomics with Ultratrace Biological Samples. Advanced Materials, 2024, 2401559

5.Qingwen Wang, Xinwen Ding, Zhixiao Xu, Boqian Wang, Aiting Wang, Liping Wang, Yi Ding, Fengda Songsun, Youming Chen, Shuang Zhang, Lai Jiang, Xianting Ding*. The mouse multi-organ proteome from infancy to adulthood, Nature Communications, 2024, (2024) 15:5752

6.Yuqing Ke#, Shiyi Huang, Behafarid Ghalandari, Sijie Li, Antony R Warden, Jingqi Dang, Lin Kang, Yu Zhang, Yunqing Wang, Yiqing Sun, Jinglin Wang, Daxiang Cui , Xiao Zhi*, Xianting Ding*, Hairpin-spacer crRNA enhanced CRISPR/Cas13a system promotes the specificity of single nucleotide polymorphisms (SNPs) identification, Advanced Science, 2021, 2003611 

7.Shuang Zhang, Behafarid Ghalandari, Aiting Wang, Sijie Li, Youming Chen, Qingwen Wang, Lai Jiang, Xianting Ding*. Superparamagnetic Composite Nanobeads Anchored with Molecular Glues for Ultrasensitive Label-free Proteomics, Angew. Chem. Int. Ed., 2023, e202309806

8.Ting Zhang, Shanhe Li, Antony R. Warden, Behafarid Ghalandari, Hongxia Li, Xiao Zhi, Haiyang Xie*, and Xianting Ding*, A Photoclick Hydrogel for Enhanced Single-cell Immunoblotting, Advanced Functional Materials, 2020, 10, 1002: 1910739

9.Hanyu Rao, Changwei Liu, Aiting Wang, Chunxiao Ma, Yue Xu, Tianbao Ye, Wenqiong Su, Peijun Zhou, Wei-Qiang Gao, Li Li*, Xianting Ding*. SETD2 Deficiency Accelerates Sphingomyelin Accumulation and Promotes the Development of Renal Cancer, Nature Communications, 2023, (2023) 14:7572

10. Yu Zhang#, Antony R. Warden, Khan Zara Ahmad, Yanlei Liu, Xijun He, Minqiao Zheng, Xinlong Huo, Xiao Zhi, Yuqing Ke, Hongxia Li, Sijia Yan, Wenqiong Su, Deng Cai, Xianting Ding*. Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown, Research, 2021: 9873545

11.Xiao Liu#, Weichen Song#, Brandon Yi-ning Wong, Ting Zhang, Shunying Yu, Guan Ning Lin*, Xianting Ding*, A comparison framework and guideline of clustering methods for mass cytometry data, Genome Biology, 2019, (2019) 20:297

12. Yilin Cai#, Shiyi Huang#, Zhinan Zhang*, Jiazheng Zhang, Xingyue Zhu, Xiaoxiang Chen, Xianting Ding*. Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultra-Minimal-Invasive Biomarker Detection with Mechanical Robustness, Research, 2022, 2022(5):1-15

13. Hongxia Li#, Antony R. Warden, Jie He, Guangxia Shen*, Xianting Ding*. Expansion Microscopy with Nine-fold Swelling (NIFS) Hydrogel Permits Cellular Ultrastructure Imaging on Conventional Microscope, Science Advances,2022, abm4003

14. Xianting Ding*, Zach Njus, Taejoon Kong, Wenqiong Su, Chih-Ming Ho and Santosh Pandey*, Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique, Science Advances, 2017,3(10):eaao1254

15. Lulu Zhang#, Xiao Liu#, Xiaoxiang Chen, Antony R Warden, Youyi Yu, Baozhen Huang, Xianting Ding*. SCANCell reveals diverse inter-cluster interaction patterns in systemic lupus erythematosus across the disease spectrum, Bioinformatics, 2021, Volume 38, Issue 5, Pages 1361–1368

16.Youyi Yu#, Xin Wang#, Xiaolong Jia, Lulu Zhang, Hongxia Li, Jie He, Guangxia Sheng*, Xianting Ding*. Aptamer Probes Labeled with Lanthanide-Doped Carbon Nanodots permit Dual-Modal Fluorescence and Mass Cytometric Imaging, Advanced Science, 2021, 2102812

17.Haiyang Xie#, Wenke Guo#, Hui Jiang#, Ting Zhang#, Lei Zhao, Jinjuan Hu, Shuxin Gao, Sunfengda Song, Jiasu Xu, Li Xu, Xinyi Sun, Yi Ding, Lai Jiang and Xianting Ding*. Photosensitive hydrogel with temperature-controlled reversible nano-apertures for single-cell protein analysis, Advanced Science, 2024,e2308569

18.Shuang Zhang, Zhixiao Xu, Youming Chen, Lai Jiang, Aiting Wang, Guangxia Shen, and Xianting Ding*. Lanthanide Metal−Organic Framework Flowers for Proteome Profiling and Biomarker Identification in Ultratrace Biofluid Samples, ACS Nano, 2025, 19(4):4377-4390

19. Haoni Yan, Aynur Abdulla, Aiting Wang, Shuyu Ding, Manlin Zhang, Yizhi Zhang,Tsz Yui Zhuang, Leqi Wu, Yan Wang, Rongrong Ren,* Lai Jiang,* and Xianting Ding*. Time-Lapse Acquisition of Both Freely Secreted Proteomeand Exosome Encapsulated Proteome in Live Organoids’ Microenvironment, Advanced Science, 2024, 2406509

20. Jie He, Hengyu Li*, John Mai, Yuqing Ke, Chunhui Zhai, Jiao Jiao Li, Lai Jiang, Guangxia Shen*, Xianting Ding*. Profiling extracellular vesicle surface proteins with 10 µL peripheral plasma within 4 h, Journal of Extracellular Vesicles, 2023, 12(9):e12364