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  丁顯廷

  意昂4平台特聘教授👈🏽、博士生導師，個性化醫學研究院常務副院長、意昂4体育平台分子與納米醫學平臺主任。國家級科技創新領軍人才、國家海外高層次人才、國家優秀青年科學基金、國家重點實驗室PI、求是基金會“求是傑出青年學者獎”、廣慈基金會“轉化醫學創新獎”🏌🏿、唐仲英基金會“仲英青年學者”💤、中國抗癌協會青年科技獎、上海市“曙光計劃”學者、上海市科協“飛翔計劃”學者、上海市優秀黨外雙創人才、意昂4平台“凱原十佳教師“、世界經濟論壇（World Economic Forum, WEF）青年科學家🍯、世界頂尖科學家論壇（World Laureates Forum, WLF）青年科學家、美國南加州中華科學家工程師協會青年科學家、微納系統與工程(Microsystems & Nanoengineering, MINE) Young Scientist Award、國際實驗室自動化與篩查協會(Society for Laboratory Automatiom and Screening, SLAS) Tony B. Academic Award、iCANX Young Scientist Award💳🤰。

  
  

          擔任比爾.蓋茨基金會(Bill & Melinda Gates Foundation)國際重大專項負責人🦹🏻‍♀️🔢、國家”重大新藥創製“科技重大專項負責人🕵️‍♂️👮🏿、國家重點研發計劃”生物安全技術“專項負責人、科技部APEC國際合作項目負責人、軍委科技委國防創新特區第一批啟動項目負責人、國家重點研發計劃”前沿和共性技術創新“課題負責人🦵🏿、國家“艾滋病和病毒性肝炎等重大傳染病防治”重大科技專項課題負責人🕍♋️、國際人類表型組計劃課題負責人、上海市科技創新行動計劃負責人🕴🏻🖐、國家自然基金項目負責人等。

  
  

          擔任6個國際SCI期刊的編委會成員，已發表包括Nature, Science Advances, Genome Biology, Advanced Materials, Angew Chemie, Nature Communications, PNAS, Nature Protocols, ACS Nano在內的國際期刊論文150余篇🎱⛈，申請國內外發明專利70余項。

  
  

          生物醫學研究中，我們往往需要面對微量生物樣本🧑‍🦼‍➡️，甚至單細胞尺度上🏫，實現與疾病相關的 1）蛋白質新靶點的發現🤽🏽‍♀️；2）靶點蛋白相互作用網絡的建立；3）超微量靶點蛋白的精準檢測。這三個方面是全球普遍的挑戰。課題組主要科研方向，面向國防安全和臨床應用，開發基於痕量生物樣本的個體化診療技術 😑：1．痕量臨床樣本(單細胞)蛋白檢驗新原理和新技術✉️；2.痕量臨床樣本（單細胞）蛋白檢驗新裝置的集成化和微型化👏🏿；3. 基於痕量臨床樣本的個體化藥物敏感性檢測新技術。

  
  

民盟中央委員💦；民盟上海市委員🌍；民盟意昂4平台副主委；上海市徐匯區政協委員。

中央JW科技委GF科技創新特區變革性交叉科學技術領域專家組專家委員、中國婦幼保健協會青年工作委員會醫教研產一體化協作組副組長👵🏻、全國腫瘤人工智能專業委員會委員、全國發酵工程技術工作委員會智能製造專業委員會委員、全國衛生產業協會實驗醫學專家委員會青年委員會委員、世界華人醫師協會前沿科技與臨床轉化專業委員會委員、上海市免疫學會免疫遺傳專業委員會常務委員、上海市藥學會藥物治療專業委員會委員🫅🏿、上海醫學會神經免疫學會委員、中國醫藥生物技術技術協會生物安全專業委員會委員。

擔任法國國家科研署（ANR）國際通訊評審🧟‍♂️、澳大利亞國立健康與醫學研究理事會（NHMRC）國際通訊評審🧑🏿‍🔧、以色列科技部（MOST Israel）國際通訊評審👀、波蘭國家科學中心（NCN）國際通訊評審👩🏻‍🎓🟦、塞爾維亞科學基金會（Science Fund of the Republic of Serbia）🦸🏻‍♀️、UK Pancreatic Cancer Research Fund (英國慈善科研機構)、Bill & Melinda Gates Foundation（美國慈善科研機構）國際通訊評審🧑🏼‍🏭。

1. 單細胞蛋白組學技術、組學大數據人工智能建模

2. 體外診斷🔝🤾🏻‍♂️，生物傳感器💡，微流控芯片技術

3. 痕量功能蛋白質富集、捕獲👮🏿‍♂️、成像的納米材料

實驗室主頁 ： http://www.dinglab.com.cn/

1. Jingqi Dang, Hongxia Li, Lulu Zhang, Sijie Li, Ting Zhang, Shiyi Huang, Yiyang Li, Chengjie Huang, Yuqing Ke, Guangxia Shen*, Xiao Zhi* and Xianting Ding*, New Structure Mass Tag based on Ab functionalized Zr-NMOF in Mass Cytometry for Multiparameter and Sensitive Single-Cell Biomarker Interrogating, Advanced Materials, 2021, 202008297

2. Shanhe Li#, Ze Wen, Behafarid Ghalandari, Tianhao Zhou, Antony R. Warden, Ting Zhang, Peng Dai, Youyi Yu, Wenke Guo, Mofang Liu, Haiyang Xie*, and Xianting Ding*, Single-cell transfection analysis chip enables high-throughput screening and accurate profiling of exogenous gene expression in single host cells, Advanced Materials, 2021, 2101108

3. Sijia Yan#, Khan Zara Ahmad, Sijie Li, Antony R. Warden, Jing Su, Yu Zhang, Youyi Yu, Xiao Zhi, Xianting Ding*, Precoated antibody proximity extension-enhanced biomarker (PROPER) assay enables trace protein detection with single-digit accuracy, Biosensors & Bioelectronics, 2021, 183:113211

4.Sijie Li#, Shiyi Huang, Yuqing Ke, Hongjun Chen, Jingqi Dang, Chengjie Huang, Wenjia Liu, Daxiang Cui, Jinglin Wang, Xiao Zhi*, Xianting Ding*, A HiPAD Integrated with rGO/MWCNTs Nano-Circuit Heater for Visual Point-of-Care Testing of SARS-CoV-2, Advanced Functional Materials, 2021, 2100801

5.Sijia Yan#, Khan Zara Ahmad, Antony R. Warden, Yuqing Ke, Nokuzola Maboyi, Xiao Zhi, Xianting Ding*. One-pot pre-coated interface proximity extension assay for ultrasensitive co-detection of anti-SARS-CoV-2 antibodies and viral RNA, Biosensors & Bioelectronics, 2021, 193 (2021) 113535

6.Yuqing Ke#, Shiyi Huang, Behafarid Ghalandari, Sijie Li, Antony R Warden, Jingqi Dang, Lin Kang, Yu Zhang, Yunqing Wang, Yiqing Sun, Jinglin Wang, Daxiang Cui , Xiao Zhi*, Xianting Ding*, Hairpin-spacer crRNA enhanced CRISPR/Cas13a system promotes the specificity of single nucleotide polymorphisms (SNPs) identification, Advanced Science, 2021, 2003611 

7.Ting Zhang#, Antony R. Warden, Yiyang Li, and Xianting Ding*, Progress and applications of mass cytometry in sketching immune landscapes, Clinical and Translational Medicine (CTM), 2020, 10(6)

8.Ting Zhang, Shanhe Li, Antony R. Warden, Behafarid Ghalandari, Hongxia Li, Xiao Zhi, Haiyang Xie*, and Xianting Ding*, A Photoclick Hydrogel for Enhanced Single-cell Immunoblotting, Advanced Functional Materials, 2020, 10, 1002: 1910739

9.Youyi Yu, Jingqi Dang, Xiao Liu, Liping Wang, Shanhe Li, Ting Zhang, Xianting Ding*, Metal-labeled Aptamers as Novel nanoprobes for Imaging Mass Cytometry Analysis, Analytical Chemistry, 2020, 92, 9, 6312-6320

10. Yu Zhang#, Antony R. Warden, Khan Zara Ahmad, Yanlei Liu, Xijun He, Minqiao Zheng, Xinlong Huo, Xiao Zhi, Yuqing Ke, Hongxia Li, Sijia Yan, Wenqiong Su, Deng Cai, Xianting Ding*. Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown, Research, 2021: 9873545

11.Xiao Liu#, Weichen Song#, Brandon Yi-ning Wong, Ting Zhang, Shunying Yu, Guan Ning Lin*, Xianting Ding*, A comparison framework and guideline of clustering methods for mass cytometry data, Genome Biology, 2019, (2019) 20:297

12. Yilin Cai#, Shiyi Huang#, Zhinan Zhang*, Jiazheng Zhang, Xingyue Zhu, Xiaoxiang Chen, Xianting Ding*. Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultra-Minimal-Invasive Biomarker Detection with Mechanical Robustness, Research, 2022, 2022(5):1-15

13. Hongxia Li#, Antony R. Warden, Jie He, Guangxia Shen*, Xianting Ding*. Expansion Microscopy with Nine-fold Swelling (NIFS) Hydrogel Permits Cellular Ultrastructure Imaging on Conventional Microscope, Science Advances,2022, abm4003

14. Xianting Ding*, Zach Njus, Taejoon Kong, Wenqiong Su, Chih-Ming Ho and Santosh Pandey*, Effective drug combination for Caenorhabditis elegans nematodes discovered by output-driven feedback system control technique, Science Advances, 2017,3(10):eaao1254

15. Lulu Zhang#, Xiao Liu#, Xiaoxiang Chen, Antony R Warden, Youyi Yu, Baozhen Huang, Xianting Ding*. SCANCell reveals diverse inter-cluster interaction patterns in systemic lupus erythematosus across the disease spectrum, Bioinformatics, 2021, Volume 38, Issue 5, Pages 1361–1368

16.Youyi Yu#, Xin Wang#, Xiaolong Jia, Lulu Zhang, Hongxia Li, Jie He, Guangxia Sheng*, Xianting Ding*. Aptamer Probes Labeled with Lanthanide-Doped Carbon Nanodots permit Dual-Modal Fluorescence and Mass Cytometric Imaging, Advanced Science, 2021, 2102812

17.Boqian Wang#, Antony R.Warden, Xianting Ding*. The Optimization of Combinatorial Drug Therapies: Strategies and Laboratorial Platforms, Drug Discovery Today, 2021, 26 (11), pp.2646-2659