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  徐宏

  徐宏，首席研究員，博士生導師。“長江學者獎勵計劃”特崗學者👨‍🎤，上海市高等學校優秀青年教師。主要從事基於微納技術的創新生物檢測及其在重大疾病早篩🐦、早診的基礎及應用研究🦶🏼👩🏽‍💼。在體外診斷用高品質功能微球的創製具有較好的理論基礎與產業化轉化經驗，並在此基礎上發展出一系列以微納技術為核心的生物檢測創新方法👩🏽‍🚒👉🏻。先後在JACS, Adv. Mater., ACS Nano, Adv. Funct. Mater., Nat. Commun, Small, Small Methods, Biosens Bioelectron. 等知名期刊上發表論文100余篇，申請或授權發明專利50多項🧑🏽‍💼，專利成果轉化率大於70%。承擔多項國家自然基金項目🗼、科技部重點項目、上海市科委、教委科技創新項目、意昂4平台醫工交叉重大🙍🏽‍♀️、重點課題以及多項重大橫向課題的研究📳。科研成果榮獲教育部技術發明一等獎🌅、自然科學二等獎以及上海市技術發明二等獎。

  
  

• 具有精密表、微觀結構的納米功能復合材料的可控製備及其與生物分子相互作用機製研究🏊🏻；

• 基於納米功能材料的超靈敏🦘、快速、多指標生物檢測新方法及其在臨床診斷的應用基礎研究

• 腫瘤、阿爾茲海默病等重大慢病的早篩👨🏿‍🔬、早診與真實世界隊列研究

1.      Weiyuan Lyu#, Jingwei Yi#, Qingsheng Guo, Yao Wang, Jiajie Zhang, Tong Sun, Haoji Ma, Tingting Tang, Xueling Quan, Hong Xu*, Feng Shen*, and Hongchen Gu, Multiplex Digital Immunoassays with Reduced Pre-partition Reaction via Massively Parallel Reagent Delivery on a Bead-Based SlipChip, ACS Nano, 2023, 17, 13, 12641–12651.

2.      Mengqiu Yan, Zhenzhen Zhao, Tao Wu, Tangyuheng Liu, Gaolian Xu*, Hong Xu*, and Binwu Ying*，Highly sensitive detection of complicated mutations of drug resistance in mycobacterium tuberculosis using a simple, accurate, rapid, and low-cost tailored-design competitive wild-type blocking assay, Small Methods, 2023, 2201322. 

3.      Gaolian Xu, Hao Yang, Jiani Qiu, Julien Reboud, Linqing Zhen, Wei Ren, Hong Xu*, Jonathan M. Cooper*, Hongchen Gu*, Sequence terminus dependent PCR for site-specific mutation and modification detection, Nature Communications, 2023, 14, 1169.

4.      Zhejia Gu, Tong Sun, Qingsheng Guo, Yao Wang, Yunfei Ge, Hongchen Gu, Gaolian Xu*, Hong Xu*, Bead-based multiplexed droplet digital polymerase chain reaction in a single tube using universal sequences: an ultrasensitive, cross-reaction-free, and high-throughput strategy, ACS Sensors, 2022, 7, 2759−2766. 

5.      Feiyang Ou#, Danyun Lai #, Xiaojun Kuang, Ping He, Yang Li, He-wei Jiang, Wei Liu, Hongping Wei, Hongchen Gu, Yuan qiao Ji, Hong Xu*, Sheng-ce Tao*, Ultrasensitive monitoring of SARS-CoV-2-specific antibody responses based on a digital approach reveals one week of IgG seroconversion, Biosensors and Bioelectronics, 2022, 217,114710. 

6.      Jingwei Yi, Zehang Gao, Qingsheng Guo, You Wu, Tong Sun, Yao Wang, Hongbo Zhou, Hongchen Gu, Jianlong Zhao, Hong Xu*, Multiplexed digital ELISA in picoliter droplets based on enzyme signal amplification block and precisely decoding strategy: A universal and practical biodetection platform, Sensors & Actuators: B. Chemical, 2022, 369, 132214. 

7.      Xiaoyu Yue, Xiaoxia Fang*, Tong Sun, Jingwei Yi, Xiaojun Kuang, Qingsheng Guo, Yao Wang, Hongchen Gu, Hong Xu*, Breaking through the Poisson Distribution: A compact high-efficiency droplet microfluidic system for single-bead encapsulation and digital immunoassay detection, Biosensors and Bioelectronics, 2022, 211, 114384

8.      Xue Wu†, Zhenxu Xiao†, Jingwei Yi, Saineng Ding, Hongchen Gu, Wanqing Wu, Jianfeng Luo, Xiaoniu Liang, Li Zheng, Hong Xu*, Qianhua Zhao*, and Ding Ding, Development of a plasma biomarker diagnostic model incorporating ultrasensitive digital immunoassay as a screening strategy for Alzheimer disease in a chinese population, Clinical Chemistry, 2021, 67, 1628-1639.

9.      Yao Wang, Cang Chen, Jing He, Yimei Cao, Xiaoxia Fang, Xiaomei Chi, Jingwei Yi, Jiancong Wu, Qingsheng Guo, Hajar Masoomi, Chongzhao Wu, Jian Ye, Hongchen Gu, Hong Xu*, Precisely encoded barcodes through the structure-fluorescence combinational strategy: A flexible, robust, and versatile multiplexed biodetection platform with ultrahigh encoding capacities, Small, 2021, 2100315.

10.   Zhenxu Xiao, Xue Wu, Wanqing Wu, Jingwei Yi, Xiaoniu Liang, Saineng Ding, Li Zheng, Jianfeng Luo, Hongchen Gu, Qianhua Zhao*, Hong Xu* and Ding Ding, Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease, Alzheimer's Research & Therapy, 2021, 13:123. 

11.   Xiaoxia Fang, Cang Chen, Bing Liu, Fenglin Hu, Hongchen Gu*, Hong Xu*, A magnetic beads-mediated selective adsorption strategy (MagExo) for extracellular vesicles separation and purification, Acta Biomaterialia, 2021, 124, 336-347.  

12.   Sitong Xu, Jiancong Wu, Cang Chen, Jiayu Zhang, Hongchen Gu, Yao Wang*, Hong Xu*, A non-isolated and high-throughput digital biodetection method via the “sphere-labeled-sphere” strategy, Sensors & Actuators: B. Chemical, 2021, 337, 129794. 

13.   Zehang Gao, Jingwei Yi, Jianlong Zhao, Hongchen Gu, Hongbo Zhou*, Hong Xu*, Droplets isolated array: A universal platform of delaying molecule cross-contamination between microdroplets for digital enzyme-based immunoassay, Sensors & Actuators: B. Chemical, 2020, 324, 128716.  

14.   Qingsheng Guo, Yao Wang, Cang Chen, Dan Wei, Jianping Fu, Hong Xu*, Hongchen Gu*, Multiplexed luminescence oxygen channeling immunoassay based on dual-functional barcodes with a Host–Guest structure: A facile and robust suspension array platform, Small, 2020, 16, 1907521. 

15.   Zhejia Gu, Simin Zhao, Gaolian Xu, Cang Chen, Yao Wang, Hongchen Gu, Yi Sun*, Hong Xu*, Solid-phase PCR based on thermostable, encoded magnetic microspheres for simple, highly sensitive and multiplexed nucleic acid detection, Sensors and Actuators B: Chemical, 2019, 298, 126953.  

16.   Fenglin Hu, Kaimin Chen, Hong Xu*, Hongchen Gu*, Design and preparation of bi-functionalized short-chain modified zwitterionic nanoparticles, Acta Biomaterialia, 2018, 72, 239–247.   

17.   Si Lu, Ding Shengzi Zhang, Dan Wei, Ye Lin, Shunjia Zhang, Hao He, Xunbin Wei, Hongchen Gu, Hong Xu*, Three-Dimensional barcodes with ultrahigh encoding capacities: A flexible, accurate, and reproducible encoding strategy for suspension arrays, Chemistry of Materials, 2017, 29, 10398−10408. 

18.   Ding Sheng-zi Zhang, Yang Jiang, Haiou Yang, Youjie Zhu, Shunjia Zhang, Ying Zhu,Dan Wei1, Ye Lin, PingPing Wang, Qihua Fu, Hong Xu*, Hongchen Gu*, Dual-Encoded microbeads through a Host-Guest structure: enormous, flexible and accurate barcodes for multiplexed assays, Advanced Functional Materials, 2016, 26, 6146-6157.  

19.   Peirui Wang, Ping Xu, Pingping Wang, Lingling Deng, Hongchen Gu, Hong Xu*, Improvement of protein immobilization and bioactivity of magnetic carriers using a brushed Beads-on-Beads structure, ACS Applied Materials & Interfaces, 2015, 7, 24390−24395. 

20.   Zhenyuan Qu, Hong Xu*, Hongchen Gu*, Synthesis and biomedical applications of poly((meth)acrylic acid) brushes, ACS Applied Materials & Interfaces, 2015, 14537–14551.   

21.   Zhenyuan Qu, Hong Xu*, Kaimin Chen, Hongchen Gu*, Ultrasensitive ELISA using enzyme-loaded nanospherical brushes as labels, Analytical Chemistry, 2014, 86, 9367-9371.

22.   Hong Xu, Longlan Cui, Naihu Tong, and Hongchen Gu, Development of high magnetization Fe3O4/Polystyrene/Silica nanospheres via combined Miniemulsion/Emulsion polymerization, Journal of The American Chemical Society, 2006,128, 15582-15583.