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  高維強

  意昂4平台王寬誠講席教授，博士生導師。

  MED-X研究院院長🐩。

  1982年南京大學本科畢業，同年進入中科院就讀研究生並入選CUSBEA項目💙，1983年赴美🦄，1989年獲哥倫比亞大學博士⛑️🖖🏿，在哥倫比亞大學醫意昂4及洛克菲勒大學完成博士後研究。1993-2010年，歷任美國Genentech公司科學家/實驗室主任👩🏿‍🎤、資深科學家🙇🏽‍♂️🥭。期間於2003年榮獲國家自然科學基金委“海外傑青”🐦‍🔥。2010年全職回國。擔任仁濟醫院幹細胞研究中心主任。

  長期致力於“幹細胞與組織發育修復”和“腫瘤發生發展（包括腫瘤幹細胞）”機製研究。近年來聚焦腫瘤幹細胞🥞🏊🏼‍♀️、耐藥性📵、診斷和靶向治療的探索以及神經損傷修復和內耳毛細胞發育再生的研究。他的研究組於2000年在Nature Neurosci.發表了內耳毛細胞再生的裏程碑研究成果； 2008年Nature雜誌對他專門做了采訪並專頁報道了他對“單個幹細胞能夠在體重建器官”和“腫瘤幹細胞理論”的見解⚾️。以通訊或第一作者在Nature, Science, Cell, Neuron, Nature Neurosci., Nature Communications, Gastroenterology, PNAS, Cancer Research 等雜誌上發表了約70篇文章。獲得48項美國專利。並受邀為美國NIH、英國Wellcome Trust、中國自然科學基金會以及40家包括Nature、Nature Medicine🪨、Cancer Cell、Nature Cell Biology🚵🏻‍♂️、Nature Communications等雜誌評審。現正承擔科技部國家重點科學研究計劃（973）項目和國家自然科學基金重點及面上項目，也是上海市教委腫瘤學重點學科負責人和上海市衛計委重中之重臨床腫瘤重點學科負責人。 

1.Yang R, Wang M, Wang J, Huang X, Yang R, Gao WQ. (2015). Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling. Stem Cell Reports. 2015 Nov 10;5(5):816-28.

2.Quan Y, Wang N, Chen Q, Xu J, Cheng W, Di M, Xia W, Gao W-Q (2015). SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway. Oncotarget. 2015 Sep 22;6(28):26494-507.

3.Zhu HH, Zhuang G, Gao W-Q (2015). A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. J Pathol. 2015 Aug 27. doi: 10.1002/path.4601. [Epub ahead of print]

4.Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao W-Q (2015). CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Aug 6. pii: canres.3590.2014. [Epub ahead of print]

5.Qin Y, Gao W-Q (2015).Concise Reviews: Patient-Derived Stem Cell Research for Monogenic Disorders. Stem Cells. 2015 Jul 31. doi: 10.1002/stem.2112. [Epub ahead of print].

5. Chang YL, Zhou PJ, Wei L, Li W, Ji Z, Fang YX, Gao W-Q (2015). MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway. Oncotarget. 2015 Sep 15;6(27):24017-31.

6. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R and Gao WQ. Autocrine activation of CHRM3 promotes prostate cancer growth and castration resistance via CaM/CaMKK-mediated phosphorylation of Akt. Clinical Cancer Research. 2015 Oct 15;21(20):4676-85.

7. Liu W, Wu H, Chen L, Wen Y, Kong X, Gao WQ. Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis. Cell Res. 2015 Jun;25(6):691-706. (IF=12.41).

8. Zhang K, Zhao H, Ji Z, Zhang C, Zhou P, Wang L, Chen Q, Wang J, Zhang P, Chen Z, Zhu HH, Gao WQ. Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 2015 Jun 8. doi: 10.1038/onc.2015.184. [Epub ahead of print]

9. Qin Y, Qin J, Zhou C, Li J, Gao WQ. Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer. Cell Cycle. 2015;14(8):1282-90.

10. Li X, Liu Y, Chen W, Fang Y, Xu H, Zhu H, Chu M, Li W, Zhuang G, Gao WQ. TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer. Oncotarget. 2014, 5(19):9498-513. IF=6.627.

11.Zhou Z, Ji Z, Wang Y, Li J, Cao H, Zhu HH, Gao WQ. TRIM59 Is Up-Regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of P53. Gastroenterology. 2014 Jul 18. pii: S0016-5085(14)00917-2. IF= 16.716.

12.Wang J, Zhu HH, Chu M, Liu Y, Zhang C, Liu G, Yang X, Yang R, Gao WQ. Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nat Commun. 2014 Aug 28;5:4758. doi: 10.1038/ncomms5758.

13.Li J, Tang YH, Wang YT, Tang RB, Jiang WF, Yang GY and Gao WQ. Neurovascular recovery via co-transplanted neural and vascular progenitors leads to improved functional restoration after ischemic stroke in rat. Stem Cell Reports. 2014 Jun 19;3(1):101-14.

14.Li J, Xuan JW, Khatamianfar V, Valiyewa F, Moussa M, Sadek A, Yang BB, Dong BJ, Huang YR, Gao WQ. SKA1 overexpression promotes centriole over duplication, centrosome amplification and prostate tumorigenesis. J Pathol. 2014 Oct;234(2):178-89.

15.Fang, Y and Gao W-Q. Roles of miRNAs during prostate tumorigenesis and tumor progression. Oncogene, 2013 Mar 4. doi: 10.1038/onc.2013.54.

16.Sun Y, Wang BE, Leong KG, Yue P, Li L, Jhunjhunwala S, Chen D, Seo K, Modrusan Z, Gao WQ*, Settleman J*, Johnson L*. Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res. 2012 Jan 15;72(2):527-36.

17.Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R,Ferrando R, Couto SS, Mohan S, Pandita A, Hongo JA, Arnott D, Wertz IE, Gao WQ, French DM, Dixit VM. COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 2011 May 15;474(7351):403-6.

18.Leong KG, Wang BE, Johnson L, Gao WQ. Generation of a prostate from a single adult stem cell. Nature. 2008 Dec 11;456(7223):804-8 （封面文章）.

19.Leow CC, Romero MS, Ross S, Polakis P, Gao WQ. Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells. Cancer Res. 2004 Sep 1;64(17):6050-7.

20.Shou J, Soriano R, Hayward SW, Cunha GR, Williams PM, Gao WQ. Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2830-5.

21.Shou J, Ross S, Koeppen H, de Sauvage FJ, Gao WQ. Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res. 2001 Oct 1;61(19):7291-7.

22.Zheng JL, Shou J, Guillemot F, Kageyama R, Gao WQ. Hes1 is a negative regulator of inner ear hair cell differentiation. Development. 2000 Nov;127(21):4551-60.

23.Zheng JL, Gao WQ. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci. 2000 Jun;3(6):580-6.

24.Yan M, Wang LC, Hymowitz SG, Schilbach S, Lee J, Goddard A, de Vos AM, Gao WQ, Dixit VM. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science. 2000 Oct 20;290(5491):523-7.

25.Zheng JL, Keller G, Gao WQ. Immunocytochemical and morphological evidence for intracellular self-repair as an important contributor to mammalian hair cell recovery. J Neurosci. 1999 Mar 15;19(6):2161-70.

26.Zheng JL, Helbig C, Gao WQ. Induction of cell proliferation by fibroblast and insulin-like growth factors in pure rat inner ear epithelial cell cultures. J Neurosci. 1997 Jan 1;17(1):216-26.

27.Zheng JL, Gao WQ. Analysis of rat vestibular hair cell development and regeneration using calretinin as an early marker. J Neurosci. 1997 Nov 1;17(21):8270-82.

28.Zheng JL, Stewart RR, Gao WQ. Neurotrophin-4/5 enhances survival of cultured spiral ganglion neurons and protects them from cisplatin neurotoxicity. J Neurosci. 1995 Jul;15(7 Pt 2):5079-87.

29.Gao WQ, Dybdal N, Shinsky N, Murnane A, Schmelzer C, Siegel M, Keller G,Hefti F, Phillips HS, Winslow JW. Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann Neurol. 1995 Jul;38(1):30-7.

30.Gao WQ, Zheng JL, Karihaloo M. Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. J Neurosci. 1995 Apr;15(4):2656-67.

31.Gao WQ, Hatten ME. Immortalizing oncogenes subvert the establishment of granule cell identity in developing cerebellum. Development. 1994 May;120(5):1059-70.

32.Gao WQ, Hatten ME. Neuronal differentiation rescued by implantation of Weaver granule cell precursors into wild-type cerebellar cortex. Science. 1993 Apr 16;260(5106):367-9.

33.Gao WQ, Liu XL, Hatten ME. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell. 1992 Mar 6;68(5):841-54 （封面文章）.

34.Gao WO, Heintz N, Hatten ME. Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro. Neuron. 1991 May;6(5):705-15.

35.Gao WQ, Macagno ER. Axon extension and retraction by leech neurons: severing early projections to peripheral targets prevents normal retraction of other projections. Neuron. 1988 Jun;1(4):269-77.