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  李力

  研究員🖋，博士生導師。北京大學學士，軍事醫學科意昂4博士，英國牛津大學博士後，曾任軍事醫學科意昂4助理研究員，中國科意昂4副研究員。在Nat Genet、Cancer Cell、 Nat Cell Biol🧙🏽‍♀️、Gut、Hepatology、Nat Commun(x4)🤳🏿、Genes Dev、PNAS等國際著名期刊發表40多篇SCI論文。其中以第一或通訊作者發表30篇，累計影響因子大於310。目前擔任國際學術期刊Biomolecules & Biomedicine編委🧑🏽‍🌾，《生物醫學工程學進展》雜誌青年編委🚢🤷🏻‍♀️，Adv. Sci.🟩、Cancer Lett.和Transl Oncol特約審稿人。

  
  

   

  Tel: 021-62933629

  E-mail: lil@sjtu.edu.cn

  
  

1999🕒，北京大學學士

2005，軍事醫學科意昂4博士

2005-2008，軍事醫學科意昂4，助理研究員

2009-2011，英國牛津大學，博士後

2012-2015，中國科意昂4上海高等研究院/上海生命科學研究院🌀，副研究員

腫瘤和發育相關疾病的發生機製和幹預手段🚸，細胞治療和器官修復，表觀遺傳學，疾病動物模型。

近年來的研究工作圍繞“組蛋白修飾與疾病”展開，在分子和細胞水平上構建了可靠的功能實驗系統，重點研究了組蛋白修飾相關分子在多種疾病和發育中的作用👷，並構建了多個疾病動物模型♔，結合動物整體表型和臨床樣本分析◾️，回答腫瘤和發育相關重大疾病的分子機理問題，為進一步研究這些疾病的分子機製與診斷治療提供了良好的理論基礎和有潛力的靶點。

作為負責人承擔2項科技部重大新藥創製👴🚣🏻‍♀️，5項國家自然科學基金委青年和面上項目，3項上海市科委基金👀，2項國家重點實驗室開放課題🎇🤤，1項意昂4平台醫工交叉基金，1項教育部留學歸國人員啟動基金和4項企業橫向課題，並作為骨幹參與2項國家重點研發計劃，1項國家自然基金重點項目和1項上海市科委重點項目。

1.      Rao H^#, Wang A^#, Xu Y, Feng W, Ma C, Wang Z, Zhang W, Su W, Gao WQ, Ding X*, Li L*. Ribosome homeostasis regulated by SETD2 preserves cell junctions and safeguards intestinal barrier. (*Co-corresponding author, in preparation)

2.      Feng W^#, Liu N^#, Liu C, Rao H, Zhang W, Xu Y, Aji R, Wang Z, Gao WQ, Li L*. NSD2 promotes cell durotaxis and drives the transition from PKD to tubulocystic renal cell carcinoma through integrin/FAK/AKT signaling. (*Corresponding author, in preparation)

3.      Fu L^#, Kuerban A^#, Han W^#, Hu D^#, Shi C, Chen K, Chen H, Hu X, Wang X, Wang X, He J, Zhang L, Zhuang T, Shi K, Ouyang K, Li J, Bao Z, Shou W, Li L*, Qu X*, Cai CL*, Ye M*. Deficit of hepatocellular SETD2-mediated histone methylation predisposes to abdominal aortic aneurysm. (*Co-corresponding author, submitted to Cell Rep. Med.)

4.      Zhang W, Feng W, Ma C, Rao H, Liu C, Xu Y, Wang Z, Aji R, Liu N, Gao WQ, Li L*. The histone methyltransferase NSD2 suppresses the formation of HCC through OXPHOS / PD-L1 axis. (*Corresponding author, submitted to Cancer Commun.)

5.      Wang Z^#, Xu Y^#, Wang D, Feng W, Rao H, Zhang W, Liu N, Aji R, Gao WQ*, Li L*. NSD2 deficiency disrupts the epigenetic landscape of auditory cells to enhance ECM expression and perturbs cochlear hair cell development. (*Co-corresponding author, Adv. Sci., Under Review)

6.      Aji R, Xu Y, Wang Z, Feng W, Gui L, Rao H, Zhang W, Liu N, Gao WQ, Li L*. Targeted Delivery of Grem1 and IL-10 by Mesenchymal Stem Cells Effectively Mitigates SETD2-Deficient Inflammatory Bowel Disease. (*Corresponding author, Theranostics. In press)

7.      Xu Y^#, Xiao X^#, Ma C, Wang Z, Feng W, Rao H, Zhang W, Liu N, Aji R, Meng X, Gao WQ*, Li L*. Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption. Clin. Transl. Med., 2024; 14(12): e70128. (*Co-corresponding author)

8.      Feng W^#, Niu N^#, Lu P, Rao H, Chen Z, Zhang W, Ma C, Liu C, Xu Y, Gao WQ, Xue J*, Li L*. Multilevel regulation of NF-κB signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis. Adv. Sci. (Weinh), 2024; 11(30): e2309387. (*Co-corresponding author)

9.      Rao H, Liu C, Wang A, Ma C, Xu Y, Ye T, Su W, Zhou P, Gao WQ, Li L*, Ding X*. SETD2 Deficiency Accelerates Sphingomyelin Accumulation and Promotes the Development of Renal Cancer. Nat. Commun., 2023; 14(1): 7572. (*Co-corresponding author)

10.   Feng W^#, Ma C^#, Rao H, Zhang W, Liu C, Xu Y, Aji R, Wang Z, Xu J, Gao WQ, Li L*. Setd2 deficiency promotes gastric tumorigenesis through inhibiting the SIRT1/FOXO pathway. Cancer Lett., 2023; 579: 216470. (*Corresponding author)

11.   Ma C, Liu M, Feng W, Rao H, Zhang W, Liu C, Xu Y, Wang Z, Teng Y, Yang X, Ni L, Xu J, Gao WQ, Lu B*, Li L*. Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signaling pathway. Clin. Transl. Med., 2023; 13(11): e1475. (*Co-corresponding author)

12.   Liu C^#, Ni L^#, Li X, Rao H, Zhu Y, Feng W, Zhang W, Ma C, Xu Y, Gui L, Wang Z, Aji R, Xu J, Gao WQ, Li L*. SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signaling pathway in the absence of VHL. Clin. Transl. Med., 2023; 13(11): e1468. (*Corresponding author)

13.   Ding Z^#, Cai T^#, Tang J, Sun H, Qi X, Zhang Y, Ji Y, Yuan L, Chang H, Ma Y, Zhou H, Li L*, Sheng H*, Qiu J*. Setd2 supports GATA3+ST2+ thymic-1 derived Tregs and suppresses intestinal inflammation. Nat. Commun., 2022; 13(1): 7468. (*Co-corresponding author)

14.   Chang J, Ji X, Deng T, Qiu J, Ding Z, Li Z, Ma Y, Hu X, Li L*, Qiu J*. Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity. Cell Rep., 2022; 38(11): 110530. (*Co-corresponding author)

15.   Chen Y, Liu M, Wang W, Li L*, Lin GN*. Loss of Setd2 associates with aberrant microRNA expression and contributes to inflammatory bowel disease progression in mice. Genomics, 2021; 113(4): 2441-54. (*Co-corresponding author)

16.   Liu M, Rao H, Liu J, Li X, Feng W, Gui L, Tang H, Xu J, Gao WQ*, Li L*. The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Experimental Colitis. Redox Biol., 2021; 43: 102004. (*Co-corresponding author)

17.   Rao H, Li X, Liu M, Liu J, Feng W, Tang H, Xu J, Gao WQ*, Li L*. Multi-level regulation of β-catenin activity by SETD2 suppresses the transition from polycystic kidney disease to clear cell renal cell carcinoma. Cancer Res., 2021; 81(13): 3554-67. (*Co-corresponding author)

18.   Li X, Liu C, Zhu Y, Rao H, Liu M, Gui L, Feng W, Tang H, Xu J, Gao WQ, Li L*. Setd2 Epidermal Deficiency Promotes Cutaneous Wound Healing via Activation of AKT/mTOR Signaling. Cell Proliferat., 2021; 54(6): e13045. (*Corresponding author)

19.   Li Y^#, Tang H^#*, Chen F^#, Chen J, Wang H, Chen Z, Duan Y, Wang X, Li L*, Ouyang K*. SETD2 is essential for terminal differentiation and enucleation of erythroblasts during fetal erythropoiesis. Biochem. Bioph. Res. Co., 2021; 552: 98-105. (*Co-corresponding author)

20.   Chen F, Chen J, Wang H, Tang H, Li Y, Huang L, Wang X, Fang X, Liu J, Li L*, Ouyang K*, Han Z*. Histone lysine methyltransferase SETD2 regulates coronary vascular development in embryonic mouse hearts. Front. Cell Dev. Biol., 2021; 9: 651655. (*Co-corresponding author)

21.   Wang W, Zhao J, Song W, Li L* and Lin GN*. Alternatively splicing interactomes identify RPL10 as a novel isoform-specific partner for NSD2. Front. Cell Dev. Biol., 2021; 9: 612019. (*Co-corresponding author)

22.   Li XJ, Li QL, Ju LG, Zhao C, Zhao LS, Du JW, Wang Y, Zheng L, Song BL, Li LY, Li L*, Wu M*. Deficiency of Histone Methyltransferase SET Domain-Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC. Hepatology, 2021; 73(5): 1797-815. (*Co-corresponding author)

23.   Liu J^#, Feng W^#, Liu M, Rao H, Li X, Teng Y, Yang X, Xu J, Gao WQ, Li L*. Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mTOR signaling. Bosnian J Basic Med., 2020; 21(4): 434-46. (*Corresponding author)

24.   Rao H^#, Li X^#, Liu M, Liu J, Li X, Xu J, Li L*, Gao WQ*. Di-Ras2 Promotes Renal Cell Carcinoma Formation by Activating the Mitogen-Activated Protein Kinase Pathway in the Absence of von Hippel-Lindau. Oncogene, 2020; 39(19): 3853-66. (*Co-corresponding author)

25.   Niu N^#, Lu P^#, Yang Y, He R, Zhang L, Shi J, Wu J, Yang M, Zhang ZG, Wang LW, Gao WQ, Habtezion A, Xiao GG, Sun YW*, Li L*, Xue J*. Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis. Gut, 2020; 69(4): 715-26. (*Co-corresponding author)

26.   Liu M^#, Sun T^#, Li N, Peng J, Fu D, Li W, Li L*, Gao WQ*. BRG1 Attenuates Colonic Inflammation and Tumorigenesis through Autophagy-dependent Oxidative Stress Sequestration. Nat. Commun., 2019; 10(1): 4614. (*Co-corresponding author)

27.   Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J*, Li L*, Gao WQ*, Zhu HH*. The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nat. Commun., 2019; 10(1): 3353. (*Co-corresponding author)

28.   Xu Q^#, Xiang Y^#, Wang Q^#, Wang L^#, Brind’Amour J, Bogutz AB, Zhang Y, Zhang B, Yu G, Xia W, Du Z, Huang C, Ma J, Zheng H, Li Y, Liu C, Walker CL, Jonasch E, Lefebvre L, Wu M, Lorincz MC, Li W*, Li L*, Xie W*. SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development. Nat. Genet., 2019; 51(5): 844-56. (*Co-corresponding author)

29.   Wang L^#, Niu N^#, Li L^#, Shao R, Ouyang H, Zou W*. H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biol., 2018; 16(11): e2006522. (#Co-1st author)

30.   Zuo X^#, Rong B^#, Li L^#, Lv R, Lan F*, Tong MH*. The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. J Biol. Chem., 2018; 293(24): 9188-97. (#Co-1st author)

31.   Sun L, Li B, Su X, Chen G, Li Y, Yu L, Li L*, Wei W*. A Ursolic Acid-derived Small Molecule Triggers Cancer Cell Death Through Hyperstimulation of Macropinocytosis. J Med. Chem., 2017; 60(15): 6638-48. (*Co-corresponding author)

32.   Shi Y, Sun L, Chen G, Zheng D, Li L*, Wei W*. A combination of the telomerase inhibitor, BIBR1532, and taxol synergistically inhibit cell proliferation in breast cancer cell lines. Target. Oncol., 2015; 10(4): 565-73. (*Co-corresponding author)

33.   Li L^#, Wang D^#, Xue M^#, Mi X, Liang Y, Wang P*. 3'UTR shortening identifies high-risk prostate cancers with targeted dysregulation of ceRNA netwok. Sci. Rep., 2014; 4: 5406. (#Co-1st author)

34.   Mould A^#, Morgan MA^#, Li L^#, Bikoff EK, Robertson EJ*. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev., 2012; 26(18): 2063-74. (#Co-1st author)

35.   Li L^#, Deng B^#, Xing G, Teng Y, Tian C, Cheng X, Yin X, Yang J, Gao X, Zhu Y, Zhang L*, Yang X*, He F*. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc. Natl. Acad. Sci. USA., 2007; 104(19): 7951-6. [Comment: PACT regulates p53 controlled network of genes. Proc. Natl. Acad. Sci. USA., In this issue, 2007; 104(19): 7731-2] (#Co-1st author)

36.   Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K, Qiu T, Pan Q, Chen Q, Zhang G, Zang Y, Tan M, Zhang J, Li Q, Wang X, Jiang J, Qin J. SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways. Cancer Cell., 2020; 38(3): 350-65.e7.

37.   Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L*, He F*. KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat. Cell Biol., 2009; 11(5): 580-91.

38.   Lu K^#, Yin X^#, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L*, He F*. Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat. Cell Biol., 2008; 10(8): 994-1002.

博士核心課程"分子納米醫學工程"

意昂4体育平台"人類疾病動物模型"

致遠意昂4"生物化學"

意昂4平台教學成果二等獎（2023年）

北京市科學技術一等獎（2017）

北京細胞生物學會首屆青年優秀論文二等獎（2009）

中國細胞生物學學會第九次會員代表大會青年優秀論文三等獎（2007）